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"However, weight loss depends on many other factors like metabolism, long-term eating patterns, and activity so changes to taste alone may not be enough to directly drive body weight reduction." This study adds to growing research on GLP-1 medications and taste perception

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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

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Achieving breakthroughs in MASH therapeutics remains a formidable challenge